mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

Xiaolei Ding; Wilhelm Bloch; Sandra Iden; Markus A. Rüegg; Michael N. Hall; Maria Leptin; Linda Partridge; Sabine A. Eming

doi:10.1038/ncomms13226

Nature Communications (Oct 2016)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

Xiaolei Ding,
Wilhelm Bloch,
Sandra Iden,
Markus A. Rüegg,
Michael N. Hall,
Maria Leptin,
Linda Partridge,
Sabine A. Eming

Affiliations

Xiaolei Ding: Department of Dermatology, University of Cologne
Wilhelm Bloch: Department of Molecular and Cellular Sport Medicine, German Sport University Cologne, Am Sportpark Müngersdorf
Sandra Iden: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Markus A. Rüegg: Biozentrum, University of Basel
Michael N. Hall: Biozentrum, University of Basel
Maria Leptin: Center for Molecular Medicine Cologne (CMMC), University of Cologne
Linda Partridge: Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Sabine A. Eming: Department of Dermatology, University of Cologne

DOI: https://doi.org/10.1038/ncomms13226
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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mTOR regulates cell growth via a protein complex including mTORC1 and mTORC2, but their role in skin morphogenesis is unclear. Here, the authors delete mTORC1 and mTORC2 from the epidermis and see epidermal deficiencies but both mTORCs play distinct roles in skin morphogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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