Nature Communications (Nov 2021)

N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

  • Yanying Wang,
  • Jing Wang,
  • Xiaoyu Li,
  • Xushen Xiong,
  • Jianyi Wang,
  • Ziheng Zhou,
  • Xiaoxiao Zhu,
  • Yang Gu,
  • Dan Dominissini,
  • Lei He,
  • Yong Tian,
  • Chengqi Yi,
  • Zusen Fan

DOI
https://doi.org/10.1038/s41467-021-26718-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 19

Abstract

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Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m1A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m1A inhibition decreases tumourigenesis in preclinical models of hepatocellular carcinoma.