Компьютерные исследования и моделирование (Apr 2013)

The dynamics of polynucleotide chain consisting of two different homogeneous sequences, divided by interface

  • Andrei Anatolevich Grinevich,
  • Artem Andreevich Ryasik,
  • L. V. Yakushevich

DOI
https://doi.org/10.20537/2076-7633-2013-5-2-241-253
Journal volume & issue
Vol. 5, no. 2
pp. 241 – 253

Abstract

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To research dynamics of inhomogeneous polynucleotide DNA chain the Y-model with no dissipation term was used. Basing on this model using numerical methods calculations were carried out, which have shown the behaviour of nonlinear conformational excitation (kink), spreading along the inhomogeneous polynucleotide chain, consisting of two different homogeneous nucleotide sequences. As numerical analysis shows there are three ways of behaviour of the nonlinear kink excitation spreading along the DNA chain. After reaching the interface between two homogeneous sequences consisting of different types of bases kink can a) reflect, b) pass the interface with acceleration (increase its velocity), c) pass the interface with deceleration (decrease its velocity).

Keywords