Heliyon (Feb 2022)

Mortality due to COVID-19 during the pandemic: A comparison of first, second and third SMAtteo COvid19 REgistry (SMACORE)

  • Valentina Zuccaro,
  • Marta Colaneri,
  • Erika Asperges,
  • Pietro Valsecchi,
  • Margherita Sambo,
  • Laura Maiocchi,
  • Paolo Sacchi,
  • Alba Muzzi,
  • Valeria Musella,
  • Sara Cutti,
  • Marco Rettani,
  • Francesco Mojoli,
  • Stefano Perlini,
  • Angelo Guido Corsico,
  • Antonio Di Sabatino,
  • Enrico Brunetti,
  • Raffaele Bruno,
  • Catherine Klersy

Journal volume & issue
Vol. 8, no. 2
p. e08895

Abstract

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COVID-19 tide had shattered on European countries with three distinct and tough waves, from March and April, 2020; October and November, 2020 and March and April, 2021 respectively. We observed a 50% reduction in the hazard of death during both wave II and III compared with wave I (HR 0.54, 95%CI 0.39–0.74 and HR 0.57, 95%CI 0.41–0.80, respectively). Sex and age were independent predictors of death. We compare in-hospital mortality of COVID-19 patients admitted at our Referral Hospital of Northern Italy during the different waves, discuss the reasons of the observed differences and suggest approaches to the challenges ahead.

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