Dual-Atom Nanozyme Eye Drops Attenuate Inflammation and Break the Vicious Cycle in Dry Eye Disease

Abstract

Highlights A dual-atom nanozyme (DAN) was successfully prepared based on Fe and Mn bimetallic single-atom embedded in N-doped carbon material and modified with hydrophilic polymer. The DAN possess excellent enzyme catalytic activity and attenuate dramatically inflammation by inhibiting the reactive oxygen species (ROS)/NLRP3 signal axis. The DAN break the vicious cycle in dry eye disease and is a potential strategy for treating dry eye disease.

Keywords

• Dry eye disease
• DAN
• Dual-atom nanozyme
• Vicious cycle
• NLRP3 inflammasome
• Nanomedicine