Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity

Abstract

Abstract Poly(ε-caprolactone) (PCL) nanofibers were prepared by electrospun, on which the cis-diamminediiodoplatinum (cis-DIDP) was loaded, cis-DIDP@PCL, which effectively overcame cis-DIDP from dissociation or premature interaction with other bimolecular groups. Meanwhile, the toxicity and cross-resistance of cis-DIDP were reduced greatly. In vitro, cis-DIDP released from the PCL nanofibers eradicated the tumor cells around twice times more than free cis-DIDP, even better than cisplatin. Furthermore, cis-DIDP@PCL could controllably release cis-DIDP in different sustained-release solution based on our experiment.

Keywords

• Electrospun nanofibers
• Drug carrier
• Cis-diamminediiodoplatinum
• Controlled release
• Anticancer reagent