Acta Scientiarum: Health Sciences (2014-03-01)

Effects of therapeutic ultrasound on haematological dynamics and fibrinogen during the inflammatory phase after muscle injury in rats

  • Luis Ulisses Signori,
  • Andre de Oliveira Teixeira,
  • Antônio Marcos Vargas da Silva,
  • Silvio Teixeira da Costa,
  • Thiago Dipp,
  • Rodrigo Della Méa Plentz

DOI
https://doi.org/10.4025/actascihealthsci.v36i1.14472
Journal volume & issue
Vol. 36, no. 1
pp. 25 – 31

Abstract

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http://dx.doi.org/10.4025/actascihealthsci.v36i1.14472 This study investigated the effects of ultrasound therapy on haematological dynamics and plasma fibrinogen during the inflammatory phase of muscle injury. Forty-eight male Wistar rats were divided into control group (CG), continuous ultrasound treated group (CTU)and pulsed ultrasound (PTU). Animals were subjected to surgical incision. A transverse lesion was made in the biceps femoris muscle (50%). CTU (1.0 MHz) was applied at 12-hour intervals on the lesion, for three days, with 0.4 W cm-2 and three minutes of duration (six applications in the total). PTU was applied in the pulsed mode 20% (2 ms on/8 ms off), maintaining the other parameters. Fibrinogen, white and red blood cells were analyzed in the 24th, 48th and 72nd hour after the injury. PTU has reduced fibrinogen levels by 20% at the 24thh and by 30% at the 48thh (p < 0.001) and haemoglobin reduction at the 72nd hour (p < 0.001), which had already occurred during the 2nd collection in the other groups. CTU favoured erythrocyte reduction at the 48th h (p = 0.003). PTU presented an anti-inflammatory effect due to plasma fibrinogen reduction, and CTU favored haemorrhage due to the reduction of erythrocytes when applied in the first 72 hours after muscle injury.

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