Microbiota, Oxidative Stress, and Skin Cancer: An Unexpected Triangle
Barbara Azzimonti,
Chiara Ballacchino,
Paola Zanetta,
Marie Angele Cucci,
Chiara Monge,
Margherita Grattarola,
Chiara Dianzani,
Giuseppina Barrera,
Stefania Pizzimenti
Affiliations
Barbara Azzimonti
Laboratory of Applied Microbiology, Department of Health Sciences (DiSS), Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy
Chiara Ballacchino
Laboratory of Applied Microbiology, Department of Health Sciences (DiSS), Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy
Paola Zanetta
Laboratory of Applied Microbiology, Department of Health Sciences (DiSS), Center for Translational Research on Allergic and Autoimmune Diseases (CAAD), School of Medicine, Università del Piemonte Orientale (UPO), Corso Trieste 15/A, 28100 Novara, Italy
Marie Angele Cucci
Department of Clinical and Biological Science, University of Turin, 10125 Turin, Italy
Chiara Monge
Department of Scienza e Tecnologia del Farmaco, University of Turin, 10125 Turin, Italy
Margherita Grattarola
Department of Clinical and Biological Science, University of Turin, 10125 Turin, Italy
Chiara Dianzani
Department of Scienza e Tecnologia del Farmaco, University of Turin, 10125 Turin, Italy
Giuseppina Barrera
Department of Clinical and Biological Science, University of Turin, 10125 Turin, Italy
Stefania Pizzimenti
Department of Clinical and Biological Science, University of Turin, 10125 Turin, Italy
Mounting evidence indicates that the microbiota, the unique combination of micro-organisms residing in a specific environment, plays an essential role in the development of a wide range of human diseases, including skin cancer. Moreover, a persistent imbalance of microbial community, named dysbiosis, can also be associated with oxidative stress, a well-known emerging force involved in the pathogenesis of several human diseases, including cutaneous malignancies. Although their interplay has been somewhat suggested, the connection between microbiota, oxidative stress, and skin cancer is a largely unexplored field. In the present review, we discuss the current knowledge on these topics, suggesting potential therapeutic strategies.
