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Childhood versus adulthood-onset autoinflammatory disorders: myths and truths intertwined

Reumatismo. 2013;65(2):55-62 DOI 10.4081/reumatismo.2013.55

 

Journal Homepage

Journal Title: Reumatismo

ISSN: 0048-7449 (Print); 2240-2683 (Online)

Publisher: PAGEPress Publications

Society/Institution: SIR

LCC Subject Category: Medicine: Internal medicine

Country of publisher: Italy

Language of fulltext: English, Italian

Full-text formats available: PDF

 

AUTHORS


L. Cantarini (Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena)

A. Vitale (Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena)

O.M. Lucherini (Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena)

I. Muscari (Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena)

F. Magnotti (Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena)

G. Brizi (Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena)

B. Frediani (Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena)

G.D. Sebastiani (U.O.C. di Reumatologia, Azienda Ospedaliera San Camillo-Forlanini, Roma)

M. Galeazzi (Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena)

D. Rigante (Institute of Pediatrics, UniversitĂ  Cattolica Sacro Cuore, Roma)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 10 weeks

 

Abstract | Full Text

Autoinflammatory disorders are characterized by spontaneous episodes of systemic inflammation deriving from inherited defects of the innate immune system. Childhood is usually the lifetime involved in most inherited autoinflammatory disorders, but a moderate number of patients may experience disease onset during adulthood. Herein we report our experience in the clinical and genetic approach to the diagnosis of autoinflammatory disorders in regard of the first 500 pediatric and adult patients evaluated during the period 2007-2012 in our Center, due to histories of periodically-recurring inflammatory attacks, giving emphasis to the differences observed according to patients’age and to the most relevant data differentiating child and adult-onset autoinflammatory disorders in the medical literature.