Integrating Host Genomics with Surveillance for Invasive Bacterial Diseases

Abstract

We tested the feasibility of linking Active Bacterial Core surveillance, a prospective, population-based surveillance system for invasive bacterial disease, to a newborn dried blood spot (nDBS) repository. Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease.

Keywords

• Active bacterial core surveillance
• Neisseria meningitidis
• blood spots
• host gene
• CD46
• dispatch