A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

Froukje Vanweert; Michael Neinast; Edmundo Erazo Tapia; Tineke van de Weijer; Joris Hoeks; Vera B. Schrauwen-Hinderling; Megan C. Blair; Marc R. Bornstein; Matthijs K. C. Hesselink; Patrick Schrauwen; Zoltan Arany; Esther Phielix

doi:10.1038/s41467-022-31249-9

Nature Communications (Jun 2022)

A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes

Froukje Vanweert,
Michael Neinast,
Edmundo Erazo Tapia,
Tineke van de Weijer,
Joris Hoeks,
Vera B. Schrauwen-Hinderling,
Megan C. Blair,
Marc R. Bornstein,
Matthijs K. C. Hesselink,
Patrick Schrauwen,
Zoltan Arany,
Esther Phielix

Affiliations

Froukje Vanweert: Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
Michael Neinast: Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia
Edmundo Erazo Tapia: Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
Tineke van de Weijer: Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
Joris Hoeks: Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
Vera B. Schrauwen-Hinderling: Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
Megan C. Blair: Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia
Marc R. Bornstein: Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia
Matthijs K. C. Hesselink: Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
Patrick Schrauwen: Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University
Zoltan Arany: Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia
Esther Phielix: Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University

DOI: https://doi.org/10.1038/s41467-022-31249-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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Evidence from preclinical models suggest that lowering levels of branched chain amino acids (BCAA) improves glucose metabolism. Here the authors report that NaPB, an accelerator of BCAA catabolism, improves peripheral insulin sensitivity in patients with type 2 diabetes in a randomized placebo-controlled crossover clinical trial.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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