ACS Central Science (Apr 2021)
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
- João Conde,
- Ruth A. Pumroy,
- Charlotte Baker,
- Tiago Rodrigues,
- Ana Guerreiro,
- Bárbara B. Sousa,
- Marta C. Marques,
- Bernardo P. de Almeida,
- Sohyon Lee,
- Elvira P. Leites,
- Daniel Picard,
- Amrita Samanta,
- Sandra H. Vaz,
- Florian Sieglitz,
- Maike Langini,
- Marc Remke,
- Rafael Roque,
- Tobias Weiss,
- Michael Weller,
- Yuhang Liu,
- Seungil Han,
- Francisco Corzana,
- Vanessa A. Morais,
- Cláudia C. Faria,
- Tânia Carvalho,
- Panagis Filippakopoulos,
- Berend Snijder,
- Nuno L. Barbosa-Morais,
- Vera Y. Moiseenkova-Bell,
- Gonçalo J. L. Bernardes
Affiliations
- João Conde
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Ruth A. Pumroy
- Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States
- Charlotte Baker
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Tiago Rodrigues
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Ana Guerreiro
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Bárbara B. Sousa
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Marta C. Marques
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Bernardo P. de Almeida
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Sohyon Lee
- Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland
- Elvira P. Leites
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Daniel Picard
- Department of Pediatric Neuro-Oncogenomics, DKFZ, Heidelberg, Germany
- Amrita Samanta
- Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States
- Sandra H. Vaz
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Florian Sieglitz
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Maike Langini
- Department of Pediatric Neuro-Oncogenomics, DKFZ, Heidelberg, Germany
- Marc Remke
- Department of Pediatric Neuro-Oncogenomics, DKFZ, Heidelberg, Germany
- Rafael Roque
- Laboratório de Neuropatologia, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte (CHLN) EPE, Lisboa, Portugal
- Tobias Weiss
- Department of Neurology and Brain Tumour Center, University Hospital Zürich and University of Zurich, Zürich, Switzerland
- Michael Weller
- Department of Neurology and Brain Tumour Center, University Hospital Zürich and University of Zurich, Zürich, Switzerland
- Yuhang Liu
- Discovery Sciences, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut, United States
- Seungil Han
- Discovery Sciences, Worldwide Research and Development, Pfizer Inc., Groton, Connecticut, United States
- Francisco Corzana
- Departamento de Química, Universidad de La Rioja, Logroño, Spain
- Vanessa A. Morais
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Cláudia C. Faria
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Tânia Carvalho
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Panagis Filippakopoulos
- Structural Genomics Consortium, Oxford University, Oxford, United Kingdom
- Berend Snijder
- Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland
- Nuno L. Barbosa-Morais
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- Vera Y. Moiseenkova-Bell
- Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States
- Gonçalo J. L. Bernardes
- Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal
- DOI
- https://doi.org/10.1021/acscentsci.1c00070
- Journal volume & issue
-
Vol. 7,
no. 5
pp. 868 – 881
Abstract
No abstracts available.
