Nature Communications (Mar 2021)
Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart
- Jacquelyn M. Walejko,
- Bridgette A. Christopher,
- Scott B. Crown,
- Guo-Fang Zhang,
- Adrian Pickar-Oliver,
- Takeshi Yoneshiro,
- Matthew W. Foster,
- Stephani Page,
- Stephan van Vliet,
- Olga Ilkayeva,
- Michael J. Muehlbauer,
- Matthew W. Carson,
- Joseph T. Brozinick,
- Craig D. Hammond,
- Ruth E. Gimeno,
- M. Arthur Moseley,
- Shingo Kajimura,
- Charles A. Gersbach,
- Christopher B. Newgard,
- Phillip J. White,
- Robert W. McGarrah
Affiliations
- Jacquelyn M. Walejko
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Bridgette A. Christopher
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Scott B. Crown
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Guo-Fang Zhang
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Adrian Pickar-Oliver
- Department of Biomedical Engineering, Duke University
- Takeshi Yoneshiro
- UCSF Diabetes Center
- Matthew W. Foster
- Duke Proteomics and Metabolomics Shared Resource, Duke University School of Medicine
- Stephani Page
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Stephan van Vliet
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Olga Ilkayeva
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Michael J. Muehlbauer
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Matthew W. Carson
- Eli Lilly and Company
- Joseph T. Brozinick
- Eli Lilly and Company
- Craig D. Hammond
- Eli Lilly and Company
- Ruth E. Gimeno
- Eli Lilly and Company
- M. Arthur Moseley
- Duke Proteomics and Metabolomics Shared Resource, Duke University School of Medicine
- Shingo Kajimura
- UCSF Diabetes Center
- Charles A. Gersbach
- Department of Biomedical Engineering, Duke University
- Christopher B. Newgard
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Phillip J. White
- Duke Molecular Physiology Institute, Duke University School of Medicine
- Robert W. McGarrah
- Duke Molecular Physiology Institute, Duke University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-21962-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Systemic modulation of branched-chain keto acid (BCKA) metabolism alters cardiac health. Here, the authors define the major fates of BCKA in the heart and demonstrate that acute exposure to BCKA levels found in obesity activates cardiac protein synthesis and markedly alters the heart phosphoproteome.
