Arabidopsis γ-H2A.X-INTERACTING PROTEIN participates in DNA damage response and safeguards chromatin stability

Tianyi Fan; Huijia Kang; Di Wu; Xinyu Zhu; Lin Huang; Jiabing Wu; Yan Zhu

doi:10.1038/s41467-022-35715-2

Nature Communications (Dec 2022)

Arabidopsis γ-H2A.X-INTERACTING PROTEIN participates in DNA damage response and safeguards chromatin stability

Tianyi Fan,
Huijia Kang,
Di Wu,
Xinyu Zhu,
Lin Huang,
Jiabing Wu,
Yan Zhu

Affiliations

Tianyi Fan: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University
Huijia Kang: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University
Di Wu: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University
Xinyu Zhu: Department of Chemical Engineering (Tanwei College), Tsinghua University
Lin Huang: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University
Jiabing Wu: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University
Yan Zhu: State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Department of Biochemistry, Institute of Plant Biology, School of Life Sciences, Fudan University

DOI: https://doi.org/10.1038/s41467-022-35715-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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γ-H2A.X is a critical signal for DNA double strand break responses. In this study, an Arabidopsis protein that interacts with γ-H2A.X and the recombinase RAD51 is shown to contribute to plant chromatin stability and integrity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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