Nature Communications (Mar 2019)
Parent of origin genetic effects on methylation in humans are common and influence complex trait variation
- Yanni Zeng,
- Carmen Amador,
- Charley Xia,
- Riccardo Marioni,
- Duncan Sproul,
- Rosie M. Walker,
- Stewart W. Morris,
- Andrew Bretherick,
- Oriol Canela-Xandri,
- Thibaud S. Boutin,
- David W. Clark,
- Archie Campbell,
- Konrad Rawlik,
- Caroline Hayward,
- Reka Nagy,
- Albert Tenesa,
- David J. Porteous,
- James F. Wilson,
- Ian J. Deary,
- Kathryn L. Evans,
- Andrew M. McIntosh,
- Pau Navarro,
- Chris S. Haley
Affiliations
- Yanni Zeng
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Carmen Amador
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Charley Xia
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Riccardo Marioni
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Duncan Sproul
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Rosie M. Walker
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Stewart W. Morris
- Centre for Genomic and Experimental Medicine, IGMM, University of Edinburgh
- Andrew Bretherick
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Oriol Canela-Xandri
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Thibaud S. Boutin
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- David W. Clark
- Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
- Archie Campbell
- Centre for Genomic and Experimental Medicine, IGMM, University of Edinburgh
- Konrad Rawlik
- The Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh
- Caroline Hayward
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Reka Nagy
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Albert Tenesa
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- David J. Porteous
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- James F. Wilson
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Ian J. Deary
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Kathryn L. Evans
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Andrew M. McIntosh
- Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh
- Pau Navarro
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Chris S. Haley
- MRC Human Genetic Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-019-09301-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Parent-of-origin effects (POE) are observed when there are different effects from alleles inherited from the two parents on phenotypic measures. Here, Zeng et al. study POE on DNA methylation in 5,101 individuals and identify genetic variants that associate with methylation variation via POE and their potential phenotypic consequences.
