Determinants of genome-wide distribution and evolution of uORFs in eukaryotes

Hong Zhang; Yirong Wang; Xinkai Wu; Xiaolu Tang; Changcheng Wu; Jian Lu

doi:10.1038/s41467-021-21394-y

Nature Communications (Feb 2021)

Determinants of genome-wide distribution and evolution of uORFs in eukaryotes

Hong Zhang,
Yirong Wang,
Xinkai Wu,
Xiaolu Tang,
Changcheng Wu,
Jian Lu

Affiliations

Hong Zhang: State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University
Yirong Wang: State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University
Xinkai Wu: State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University
Xiaolu Tang: State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University
Changcheng Wu: State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University
Jian Lu: State Key Laboratory of Protein and Plant Gene Research, Center for Bioinformatics, School of Life Sciences, Peking University

DOI: https://doi.org/10.1038/s41467-021-21394-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Upstream open reading frames (uORFs) have widespread regulatory functions in eukaryotes, their genomic distribution and evolution is understudied. Here, the authors characterise ~17 million putative uORFs across 478 eukaryotic species, showing how evolution has shaped uORF contents and distribution.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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