Nature Communications (Jul 2019)

Paternal-age-related de novo mutations and risk for five disorders

  • Jacob L. Taylor,
  • Jean-Christophe P. G. Debost,
  • Sarah U. Morton,
  • Emilie M. Wigdor,
  • Henrike O. Heyne,
  • Dennis Lal,
  • Daniel P. Howrigan,
  • Alex Bloemendal,
  • Janne T. Larsen,
  • Jack A. Kosmicki,
  • Daniel J. Weiner,
  • Jason Homsy,
  • Jonathan G. Seidman,
  • Christine E. Seidman,
  • Esben Agerbo,
  • John J. McGrath,
  • Preben Bo Mortensen,
  • Liselotte Petersen,
  • Mark J. Daly,
  • Elise B. Robinson

DOI
https://doi.org/10.1038/s41467-019-11039-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

Read online

Advanced paternal age associates with increased risk for psychiatric and developmental disorders in offspring. Here, Taylor et al. utilize parent-child trio exome sequencing data sets to estimate the contribution of paternal age-related de novo mutations to multiple disorders, including heart disease and schizophrenia.