EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cells

Abstract

Interleukin 9 (IL-9) producing helper T cells (Th) have established roles in a range of inflammatory conditions and a number of transcription factors have been shown crucial for the generation of these IL-9 producing cells. Here, the authors establish a role for the EGFR-HIF1α axis in the regulation of IL-9 producing Th cell populations.