Timing and Amplitude of Light Exposure, Not Photoperiod, Predict Blood Lipids in Arctic Residents: A Circadian Light Hypothesis
Denis Gubin,
Sergey Kolomeichuk,
Konstantin Danilenko,
Oliver Stefani,
Alexander Markov,
Ivan Petrov,
Kirill Voronin,
Marina Mezhakova,
Mikhail Borisenkov,
Aislu Shigabaeva,
Julia Boldyreva,
Julianna Petrova,
Larisa Alkhimova,
Dietmar Weinert,
Germaine Cornelissen
Affiliations
Denis Gubin
Department of Biology, Tyumen Medical University, 625023 Tyumen, Russia
Sergey Kolomeichuk
Laboratory for Genomics, Proteomics, and Metabolomics, Research Institute of Biomedicine and Biomedical Technologies, Medical University, 625023 Tyumen, Russia
Konstantin Danilenko
Laboratory for Chronobiology and Chronomedicine, Research Institute of Biomedicine and Biomedical Technologies, Tyumen Medical University, 625023 Tyumen, Russia
Oliver Stefani
Department Engineering and Architecture, Lucerne University of Applied Sciences and Arts, 6048 Horw, Switzerland
Alexander Markov
Laboratory for Genomics, Proteomics, and Metabolomics, Research Institute of Biomedicine and Biomedical Technologies, Medical University, 625023 Tyumen, Russia
Ivan Petrov
Department of Biological & Medical Physics UNESCO, Medical University, 625023 Tyumen, Russia
Kirill Voronin
Laboratory for Genomics, Proteomics, and Metabolomics, Research Institute of Biomedicine and Biomedical Technologies, Medical University, 625023 Tyumen, Russia
Marina Mezhakova
Laboratory for Genomics, Proteomics, and Metabolomics, Research Institute of Biomedicine and Biomedical Technologies, Medical University, 625023 Tyumen, Russia
Mikhail Borisenkov
Department of Molecular Immunology and Biotechnology, Institute of Physiology of the Federal Research Centre Komi Science Centre of the Ural Branch of the Russian Academy of Sciences, 167982 Syktyvkar, Russia
Aislu Shigabaeva
Laboratory for Chronobiology and Chronomedicine, Research Institute of Biomedicine and Biomedical Technologies, Tyumen Medical University, 625023 Tyumen, Russia
Julia Boldyreva
Laboratory for Chronobiology and Chronomedicine, Research Institute of Biomedicine and Biomedical Technologies, Tyumen Medical University, 625023 Tyumen, Russia
Julianna Petrova
Department of Biological & Medical Physics UNESCO, Medical University, 625023 Tyumen, Russia
Larisa Alkhimova
School of Natural Sciences, University of Tyumen, 15a Perekopskaya St., 625003 Tyumen, Russia
Dietmar Weinert
Institute of Biology/Zoology, Martin Luther University, Halle-Wittenberg, 06120 Halle, Germany
Germaine Cornelissen
Department of Integrated Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA
In Arctic residents, blood lipids fluctuate seasonally in response to changes in light exposure (LE) patterns. This study investigates which aspects of LE (timing, dynamic range, and duration) are related to lipid profiles. We analyzed actigraphy data measuring LE and blue light exposure (BLE) along with blood determinations from 27 residents across different seasons. We assessed circadian parameters of melatonin in a subset of participants. We found that features of BLE and melatonin significantly predicted lipids: An earlier BLE acrophase was associated with higher HDL-C (β = −0.246, p = 0.013). Nighttime BLE was positively associated with TC (β = 0.290, p = 0.008) and LDL-C (β = 0.253, p = 0.025). The normalized circadian amplitude of BLE was inversely associated with the TG/HDL ratio (β = −0.384, p p = 0.007). Results remained significant after adjusting for co-factors of photoperiod duration, age, sex, and indigeneity. These findings suggest that patterns of LE (circadian light hygiene) could be a way to improve cardiovascular health.
