N-type fast inactivation of a eukaryotic voltage-gated sodium channel

Jiangtao Zhang; Yiqiang Shi; Junping Fan; Huiwen Chen; Zhanyi Xia; Bo Huang; Juquan Jiang; Jianke Gong; Zhuo Huang; Daohua Jiang

doi:10.1038/s41467-022-30400-w

Nature Communications (May 2022)

N-type fast inactivation of a eukaryotic voltage-gated sodium channel

Jiangtao Zhang,
Yiqiang Shi,
Junping Fan,
Huiwen Chen,
Zhanyi Xia,
Bo Huang,
Juquan Jiang,
Jianke Gong,
Zhuo Huang,
Daohua Jiang

Affiliations

Jiangtao Zhang: College of Life Science and Technology, Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology
Yiqiang Shi: State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center
Junping Fan: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Synthetic and Functional Biomolecules Center, and Peking-Tsinghua Center for Life Sciences, Peking University
Huiwen Chen: National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Zhanyi Xia: Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences
Bo Huang: Beijing StoneWise Technology Co Ltd.
Juquan Jiang: Department of Microbiology and Biotechnology, College of Life Sciences, Northeast Agricultural University
Jianke Gong: College of Life Science and Technology, Key Laboratory of Molecular Biophysics of MOE, Huazhong University of Science and Technology
Zhuo Huang: State Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University Health Science Center
Daohua Jiang: Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-30400-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Voltage-gated sodium channels mediate electrical signaling. Here, authors report the cryo-EM structure of NaVEh from the marine plant Emiliania huxleyi, revealing an unexpected mechanism of N-type fast inactivation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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