Nature Communications (Jul 2019)
Boosting NAD+ with a small molecule that activates NAMPT
- Stephen J. Gardell,
- Meghan Hopf,
- Asima Khan,
- Mauro Dispagna,
- E. Hampton Sessions,
- Rebecca Falter,
- Nidhi Kapoor,
- Jeanne Brooks,
- Jeffrey Culver,
- Chris Petucci,
- Chen-Ting Ma,
- Steven E. Cohen,
- Jun Tanaka,
- Emmanuel S. Burgos,
- Jennifer S. Hirschi,
- Steven R. Smith,
- Eduard Sergienko,
- Anthony B. Pinkerton
Affiliations
- Stephen J. Gardell
- Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
- Meghan Hopf
- Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
- Asima Khan
- Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
- Mauro Dispagna
- Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
- E. Hampton Sessions
- Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
- Rebecca Falter
- Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
- Nidhi Kapoor
- Translational Research Institute for Metabolism and Diabetes, AdventHealth-Orlando
- Jeanne Brooks
- Metabolomics Core Facility, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
- Jeffrey Culver
- Metabolomics Core Facility, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
- Chris Petucci
- Metabolomics Core Facility, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
- Chen-Ting Ma
- Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute
- Steven E. Cohen
- Daiichi Sankyo, Inc., Global Business Development
- Jun Tanaka
- Daiichi Sankyo Co., Ltd, Shinagawa Research & Development Center
- Emmanuel S. Burgos
- Department of Biochemistry, Albert Einstein College of Medicine
- Jennifer S. Hirschi
- Department of Chemistry, Binghamton University
- Steven R. Smith
- Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona
- Eduard Sergienko
- Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute
- Anthony B. Pinkerton
- Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute
- DOI
- https://doi.org/10.1038/s41467-019-11078-z
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the rate determining step for NAD+ synthesis and is of interest as a drug target. Here the authors identify and characterize a small molecule NAMPT activator SBI-797812, elucidate its mode of action and show that it increases intracellular NMN and NAD+ levels in cultured cells and elevates liver NAD+ in mice.
