Nature Communications (Sep 2022)
Structural basis for Gemin5 decamer-mediated mRNA binding
- Qiong Guo,
- Shidong Zhao,
- Rosario Francisco-Velilla,
- Jiahai Zhang,
- Azman Embarc-Buh,
- Salvador Abellan,
- Mengqi Lv,
- Peiping Tang,
- Qingguo Gong,
- Huaizong Shen,
- Linfeng Sun,
- Xuebiao Yao,
- Jinrong Min,
- Yunyu Shi,
- Encarnacion Martínez-Salas,
- Kaiming Zhang,
- Chao Xu
Affiliations
- Qiong Guo
- MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Shidong Zhao
- MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Rosario Francisco-Velilla
- Centro de Biología Molecular Severo Ochoa, CSIC-UAM
- Jiahai Zhang
- MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Azman Embarc-Buh
- Centro de Biología Molecular Severo Ochoa, CSIC-UAM
- Salvador Abellan
- Centro de Biología Molecular Severo Ochoa, CSIC-UAM
- Mengqi Lv
- MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Peiping Tang
- MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Qingguo Gong
- MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Huaizong Shen
- Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University
- Linfeng Sun
- MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Xuebiao Yao
- MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Jinrong Min
- Structural Genomics Consortium, University of Toronto
- Yunyu Shi
- MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Encarnacion Martínez-Salas
- Centro de Biología Molecular Severo Ochoa, CSIC-UAM
- Kaiming Zhang
- MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- Chao Xu
- MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China
- DOI
- https://doi.org/10.1038/s41467-022-32883-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
Structural biology, complemented by biochemistry experiments and RNA-binding assays show that the Gemin5 C-terminal region adopts a decamer architecture. Gemin5 decamerization is essential for its role in regulating mRNA translation.
