BMJ Open (Sep 2024)
Cohort profile: the Swiss Mother and Child HIV Cohort Study (MoCHiV)
- ,
- PA Crisinel,
- P Paioni,
- N Müller,
- A Anagnostopoulos,
- M Hoffmann,
- Huldrych Günthard,
- J Böni,
- J Schüpbach,
- M Baumann,
- D Nadal,
- Christoph Rudin,
- M Egger,
- C-A Siegrist,
- N Wagner,
- J Németh,
- A Duppenthaler,
- J Notter,
- L Kaiser,
- J-J CHESEAUX,
- P Schmid,
- A Rauch,
- M Huber,
- C Rudin,
- B Ledergerber,
- A Calmy,
- M Cavassini,
- M Rickenbach,
- H Furrer,
- M Battegay,
- L Elzi,
- Andri Rauch,
- B Hirschel,
- E Bernasconi,
- HC Bucher,
- J Fehr,
- J Fellay,
- CA Fux,
- D Haerry,
- B Hasse,
- HH Hirsch,
- I Hösli,
- O Keiser,
- T Klimkait,
- H Kovari,
- B Martinez de Tejada,
- G Pantaleo,
- R Speck,
- P Tarr,
- A Trkola,
- S Yerly,
- P Francioli,
- Andrea Duppenthaler,
- Karoline Aebi-Popp,
- Noemie Wagner,
- Paolo Paioni,
- Murezi Capaul,
- Anja Brunner,
- Anna Traytel,
- Pierre-Alex Crisinel,
- Begona Martinez De Tejada,
- Lisa Kottanattu,
- Marcel Stöckle,
- Irene Hösli,
- Alexandra Scherrer,
- Katharina Kusejko,
- Christian R Kahlert,
- I Abela,
- K Aebi-Popp,
- DL Braun,
- A Ciuffi,
- K Darling,
- G Dollenmaier,
- K Francini,
- HF Günthard,
- A Hachfeld,
- D Jackson-Perry,
- CR Kahlert,
- E Kapfhammer,
- M Kohns,
- L Kottanattu,
- RD Kouyos,
- K Kusejko,
- N Labhardt,
- C Marzolini,
- KJ Metzner,
- D Nicca,
- M Perreau,
- Polli Ch,
- L Salazar-Vizcaya,
- M Stöckle,
- M Thanh Lecompte,
- G Wandeler,
- M Weisser,
- C Kind
Affiliations
- PA Crisinel
- P Paioni
- N Müller
- A Anagnostopoulos
- M Hoffmann
- Huldrych Günthard
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
- J Böni
- J Schüpbach
- M Baumann
- D Nadal
- Christoph Rudin
- University Children`s Hospital Basel, Basel, Switzerland
- M Egger
- C-A Siegrist
- N Wagner
- J Németh
- A Duppenthaler
- J Notter
- L Kaiser
- J-J CHESEAUX
- P Schmid
- A Rauch
- M Huber
- C Rudin
- B Ledergerber
- A Calmy
- M Cavassini
- M Rickenbach
- H Furrer
- M Battegay
- L Elzi
- Andri Rauch
- Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland
- B Hirschel
- E Bernasconi
- HC Bucher
- J Fehr
- J Fellay
- CA Fux
- D Haerry
- B Hasse
- HH Hirsch
- I Hösli
- O Keiser
- T Klimkait
- H Kovari
- B Martinez de Tejada
- G Pantaleo
- R Speck
- P Tarr
- A Trkola
- S Yerly
- P Francioli
- Andrea Duppenthaler
- Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland
- Karoline Aebi-Popp
- Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland
- Noemie Wagner
- Pediatric Infectious Diseases Unit, Department of Pediatrics, Gynecology and Obstetrics, Geneva University Hospitals, Geneve, Switzerland
- Paolo Paioni
- Division of Infectious Diseases and Hospital Epidemiology, University Children’s Hospital Zurich, Zurich, Switzerland
- Murezi Capaul
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
- Anja Brunner
- Frauenklinik, Bürgerspital Solothurn, Solothurn, Switzerland
- Anna Traytel
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
- Pierre-Alex Crisinel
- Unit of Pediatric Infectious Diseases and Vaccinology, Department of Woman Mother and Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- Begona Martinez De Tejada
- Obstetrics Division. Department of Pediatrics, Gynecology and Obstetrics, University Hospitals Geneva, University of Geneva, Geneva, Switzerland
- Lisa Kottanattu
- Institute of Pediatrics of Southern Switzerland, EOC, Bellinzona, Switzerland
- Marcel Stöckle
- Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University Basel, Basel, Switzerland
- Irene Hösli
- Department of Obstetrics, University Hospital Basel, Basel, Switzerland
- Alexandra Scherrer
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
- Katharina Kusejko
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland
- Christian R Kahlert
- Cantonal Hospital St. Gallen, Department of Infectious Diseases, Infection Prevention and Travel Medicine, St Gallen, Switzerland
- I Abela
- K Aebi-Popp
- DL Braun
- A Ciuffi
- K Darling
- G Dollenmaier
- K Francini
- HF Günthard
- A Hachfeld
- D Jackson-Perry
- CR Kahlert
- E Kapfhammer
- M Kohns
- L Kottanattu
- RD Kouyos
- K Kusejko
- N Labhardt
- C Marzolini
- KJ Metzner
- D Nicca
- M Perreau
- Polli Ch
- L Salazar-Vizcaya
- M Stöckle
- M Thanh Lecompte
- G Wandeler
- M Weisser
- C Kind
- DOI
- https://doi.org/10.1136/bmjopen-2024-086543
- Journal volume & issue
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Vol. 14,
no. 9
Abstract
Purpose Prospective, multicentric observational cohort study in Switzerland investigating measures to prevent mother-to-child transmission in pregnant women with HIV (WWH) and assessing health and development of their exposed children as well as of children with HIV (CWH) in general.Participants Between January 1986 and December 2022, a total of 1446 mother–child pairs were enrolled. During the same period, the study also registered 187 CWH and 521 HIV-exposed but uninfected children (HEU), for whom detailed maternal information was not available. Consequently, the cohort comprises a total of 2154 children.Findings to date During these 37 years, research by the Swiss Mother and Child HIV Cohort Study (MoCHiV) and its international collaborators has strongly influenced the prevention of vertical transmission of HIV (eg, introduction and discontinuation of elective caesarean section, neonatal postexposure prophylaxis and breastfeeding). Contributions have also been made to the management of diagnostics (eg, p24 antigen assay) and the effects of antiretroviral treatment (eg, prematurity, growth) in HEU and CWH.Future plans Most children present within the cohort are now HEU, highlighting the need to investigate other vertically transmitted pathogens such as hepatitis B and C viruses, cytomegalovirus or Treponema pallidum. In addition, analyses are planned on the longitudinal health status of CWH (eg, resistance and prolonged exposure to antiretroviral therapy), on social aspects including stigma in CWH and HEU, and on interventions to further optimise antenatal and postpartum care in WWH.
