Nature Communications (Feb 2020)

Combined burden and functional impact tests for cancer driver discovery using DriverPower

  • Shimin Shuai,
  • PCAWG Drivers and Functional Interpretation Working Group,
  • Steven Gallinger,
  • Lincoln Stein,
  • PCAWG Consortium

DOI
https://doi.org/10.1038/s41467-019-13929-1
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 12

Abstract

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Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.