The decisive role of fumarase: Responsive signaling to glucose deficiency

Qiujing Yu; Ting Wang; Yuhui Jiang

doi:10.1080/23723556.2017.1363848

Molecular & Cellular Oncology (Jul 2018)

The decisive role of fumarase: Responsive signaling to glucose deficiency

Qiujing Yu,
Ting Wang,
Yuhui Jiang

Affiliations

Qiujing Yu: The Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
Ting Wang: The Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine
Yuhui Jiang: The Institute of Cell Metabolism, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine

DOI: https://doi.org/10.1080/23723556.2017.1363848
Journal volume & issue: Vol. 5, no. 4

Abstract

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Our recent study shows that AMPK normally phosphorates fumarase (FH) at Ser75 under glucose deprivation, resulting in FH-ATF2 complex formation that facilitates transcription for cell growth arrest. Meanwhile, O-GlcNAc transferase can compete with AMPK to O-GlcNAcylate FH. In tumor cells, FH is highly O-GlcNAcylated and is proinhibited from AMPK-ATF2 signaling.

Published in Molecular & Cellular Oncology

ISSN: 2372-3556 (Online)
Publisher: Taylor & Francis Group
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.tandfonline.com/journals/kmco20

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