Biomolecules (Mar 2024)
Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression
- Natalia A. Osna,
- Irina Tikhanovich,
- Martí Ortega-Ribera,
- Sebastian Mueller,
- Chaowen Zheng,
- Johannes Mueller,
- Siyuan Li,
- Sadatsugu Sakane,
- Raquel Carvalho Gontijo Weber,
- Hyun Young Kim,
- Wonseok Lee,
- Souradipta Ganguly,
- Yusuke Kimura,
- Xiao Liu,
- Debanjan Dhar,
- Karin Diggle,
- David A. Brenner,
- Tatiana Kisseleva,
- Neha Attal,
- Iain H. McKillop,
- Shilpa Chokshi,
- Ram Mahato,
- Karuna Rasineni,
- Gyongyi Szabo,
- Kusum K. Kharbanda
Affiliations
- Natalia A. Osna
- Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68106, USA
- Irina Tikhanovich
- Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA
- Martí Ortega-Ribera
- Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
- Sebastian Mueller
- Center for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany
- Chaowen Zheng
- Center for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany
- Johannes Mueller
- Center for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany
- Siyuan Li
- Center for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany
- Sadatsugu Sakane
- Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
- Raquel Carvalho Gontijo Weber
- Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
- Hyun Young Kim
- Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
- Wonseok Lee
- Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
- Souradipta Ganguly
- Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
- Yusuke Kimura
- Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
- Xiao Liu
- Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
- Debanjan Dhar
- Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
- Karin Diggle
- Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
- David A. Brenner
- Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
- Tatiana Kisseleva
- Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA
- Neha Attal
- Department of Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA
- Iain H. McKillop
- Department of Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA
- Shilpa Chokshi
- The Roger Williams Institute of Hepatology, Foundation for Liver Research, London SE59NT, UK
- Ram Mahato
- Department of Pharmaceutical Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68106, USA
- Karuna Rasineni
- Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68106, USA
- Gyongyi Szabo
- Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
- Kusum K. Kharbanda
- Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68106, USA
- DOI
- https://doi.org/10.3390/biom14040404
- Journal volume & issue
-
Vol. 14,
no. 4
p. 404
Abstract
Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and disease severity. Here, we overview several crucial mechanisms related to ALD end-stage outcome development, such as epigenetic changes, cell death, hemolysis, hepatic stellate cells activation, and hepatic fatty acid binding protein 4. Additionally, in this review, we also present two clinically relevant models using human precision-cut liver slices and hepatic organoids to examine ALD pathogenesis and progression.
Keywords
