Bile acid signaling and bariatric surgery

Jingyan Tian; Silvia Huang; Siming Sun; Lili Ding; Eryun Zhang; Yanjun Liu; Wendong Huang

Liver Research (Dec 2017)

Bile acid signaling and bariatric surgery

Jingyan Tian,
Silvia Huang,
Siming Sun,
Lili Ding,
Eryun Zhang,
Yanjun Liu,
Wendong Huang

Affiliations

Jingyan Tian: National Clinical Research Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA, USA
Silvia Huang: Eugene Robert Summer Program, City of Hope, Duarte, CA, USA
Siming Sun: Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA, USA
Lili Ding: Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA, USA; Shanghai Key Laboratory of Compound Chinese Medicines and the Ministry of Education (MOE) Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Eryun Zhang: Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA, USA; Shanghai Key Laboratory of Compound Chinese Medicines and the Ministry of Education (MOE) Key Laboratory of Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Yanjun Liu: Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA, USA
Wendong Huang: Department of Diabetes Complications and Metabolism, Beckman Research Institute of City of Hope, Duarte, CA, USA; Corresponding author.

Journal volume & issue: Vol. 1, no. 4
pp. 208 – 213

Abstract

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The rapid worldwide rise in obesity rates over the past few decades imposes an urgent need to develop effective strategies for treating obesity and associated metabolic complications. Bariatric surgical procedures, such as Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG), currently provide the most effective treatment for obesity and type 2 diabetes (T2D), as well as for non-alcoholic steatohepatitis (NASH). However, the underlying mechanisms of the beneficial effects of bariatric surgery remain elusive. Recent studies have identified bile acids as potential signaling molecules involved in the beneficial effects of bariatric surgery. This review focuses on the most recent studies on the roles of bile acids and bile acid receptors Farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 5 (TGR5) in bariatric surgery. We also discuss the possibility of modulating bile acid signaling as a pharmacological therapeutic approach to treating obesity and its associated metabolic complications. Keywords: Bile acid (BA), Bariatric surgery, Farnesoid X receptor (FXR), G protein-coupled bile acid receptor 5 (TGR5), Microbiota

Published in Liver Research

ISSN: 2096-2878 (Print); 2542-5684 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology
Website: https://www.keaipublishing.com/en/journals/liver-research/

About the journal