Journal of Pediatric Surgery Case Reports (Dec 2022)
Type II pleuropulmonary blastoma with DICER1 mutation
- Taichi Fukuzawa,
- Yuki Endo,
- Masahiro Irie,
- Hideyuki Sasaki,
- Hironori Kudo,
- Megumi Nakamura,
- Ryo Ando,
- Ryuji Okubo,
- Tsuyoshi Sakurai,
- Masatoshi Hashimoto,
- Keisuke Tada,
- Yudai Nakajima,
- Kosuke Sato,
- Ryoma Endo,
- Hidekazu Aoki,
- Saori Katayama,
- Tomohiro Nakano,
- Motoshi Wada
Affiliations
- Taichi Fukuzawa
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Yuki Endo
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Masahiro Irie
- Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Hideyuki Sasaki
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Hironori Kudo
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Megumi Nakamura
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Ryo Ando
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Ryuji Okubo
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Tsuyoshi Sakurai
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Masatoshi Hashimoto
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Keisuke Tada
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Yudai Nakajima
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Kosuke Sato
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Ryoma Endo
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Hidekazu Aoki
- Department of Diagnostic Radiology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Saori Katayama
- Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Tomohiro Nakano
- Department of Pediatrics, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan
- Motoshi Wada
- Department of Pediatric Surgery, Tohoku University Graduate School of Medicine, 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan; Corresponding author. 1-1, Seiryo-machi, Aoba-ku, Sendai-shi, Miyagi, 980-8574, Japan.
- Journal volume & issue
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Vol. 87
p. 102468
Abstract
Pleuropulmonary blastoma (PPB) is a rare tumor that arises from mesenchymal cells of the lung or pleura. PPB is classified as type I (cystic), type Ir (regressed), type II (cystic and solid), or type III (solid). Here, we report the case of a 2-year-old boy with type II PPB. The patient was treated with neoadjuvant chemotherapy, and the tumor was completely surgically resected. A DICER1 mutation was detected in the tumor specimen. The risk of recurrence is high, and long–term follow–up is required.
