A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis

Abstract

Ferroptosis is lipid peroxidation-dependent cell death that has potential to be harnessed as a cancer therapeutic. Here, the authors show that the translation initiation factor eIF4E can repress ALDH1B1 independent of translation, increasing lipid peroxidation levels to promote ferroptosis.