The Effects of Neopterin on the Viability and Motility of Different HCC Cell Lines

Abstract

Increased neopterin levels reflect the activation of the cellular immune system which is of importance in the pathogenesis and progression of various diseases such as cancer. However, the effects of neopterin on the biological activity of Hepatocellular carcinoma cells are not yet illuminated. In this study we aim to find the effects of neopterin on viability/cytotxicity and motility of five different HCC cell lines with MTT, SRB and wound healing assays. According to our results, HCC cell lines can be grouped into two categories based on their proliferative and motility response to neopterin, as sensitive and resistant. This data provides us with variable results concerning the proliferation and motility of the cell lines under the effect of neopterin. The underlying molecular mechanisms will be examined in further studies, with a focus on the effect of neopterin on the signalling pathways. Overall, neopterin might have an important role in the hepatocarcinogenesis.

Keywords

• HCC
• neopterin
• proliferation and motility