Evaluation of Six Patients with Pulmonary Carcinosarcoma with a Literature Review

The Scientific World Journal. 2012;2012 DOI 10.1100/2012/167317

 

Journal Homepage

Journal Title: The Scientific World Journal

ISSN: 2356-6140 (Print); 1537-744X (Online)

Publisher: Hindawi Limited

LCC Subject Category: Technology | Medicine | Science

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML, ePUB, XML

 

AUTHORS

Sinem Nedime Sökücü (Department of Pulmonology, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Zeytinburnu, 34760 İstanbul, Turkey)
Celalettin Kocatürk (Department of Thoracic Surgery, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Zeytinburnu, 34760 İstanbul, Turkey)
Nur Ürer (Department of Pathology, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Zeytinburnu, 34760 İstanbul, Turkey)
Yaşar Sönmezoğlu (Department of Thoracic Surgery, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Zeytinburnu, 34760 İstanbul, Turkey)
Levent Dalar (Department of Pulmonology, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Zeytinburnu, 34760 İstanbul, Turkey)
Levent Karasulu (Department of Pulmonology, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Zeytinburnu, 34760 İstanbul, Turkey)
Sedat Altın (Department of Pulmonology, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Zeytinburnu, 34760 İstanbul, Turkey)
Mehmet Ali Bedirhan (Department of Thoracic Surgery, Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital, Zeytinburnu, 34760 İstanbul, Turkey)

EDITORIAL INFORMATION

Blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 17 weeks

 

Abstract | Full Text

Background. Carcinosarcoma of the lung is a rare malignant neoplasm. We evaluated the diagnosis and treatment of six carcinosarcoma cases, including a synchronous tumour and a solitary pulmonary tumour, along with the clinical and histological features and survival times. Methods. From a retrospective analysis of 1076 non-small-cell lung cancer resections performed between January 1996 and January 2011, six patients (0.5%) with pulmonary carcinosarcoma (all males; mean age 58 years; range 53–66) who underwent surgical treatment were studied. Results. The mean tumour pathological T diameter was 7.2 cm (median 6 cm, range 3–14.5 cm). Only one patient was diagnosed with carcinosarcoma preoperatively. The clinical presentation and tumour localisations differed. The operations performed were a lobectomy (n=4), pneumonectomy (n=1), and bilobectomy (n=1). Histologically, the epithelial characteristics of the tumours were consistent with squamous cell carcinoma in most of the patients. A complete resection was performed in all six patients. No mortality occurred in the early postoperative period. The median survival time was 9 (3–25) months. Conclusion. The preoperative diagnosis of carcinosarcoma of the lung is difficult due to the composition of the different histopathological structures. Complete surgical resection is the treatment of choice for pulmonary carcinosarcoma, although further studies are needed.