Nature Communications (Feb 2016)
Downregulation of TLX induces TET3 expression and inhibits glioblastoma stem cell self-renewal and tumorigenesis
- Qi Cui,
- Su Yang,
- Peng Ye,
- E. Tian,
- Guoqiang Sun,
- Jiehua Zhou,
- Guihua Sun,
- Xiaoxuan Liu,
- Chao Chen,
- Kiyohito Murai,
- Chunnian Zhao,
- Krist T. Azizian,
- Lu Yang,
- Charles Warden,
- Xiwei Wu,
- Massimo D'Apuzzo,
- Christine Brown,
- Behnam Badie,
- Ling Peng,
- Arthur D. Riggs,
- John J. Rossi,
- Yanhong Shi
Affiliations
- Qi Cui
- Department of Developmental and Stem Cell Biology, Division of Stem Cell Biology Research, Cancer Center, Beckman Research Institute of City of Hope
- Su Yang
- Department of Developmental and Stem Cell Biology, Division of Stem Cell Biology Research, Cancer Center, Beckman Research Institute of City of Hope
- Peng Ye
- Department of Developmental and Stem Cell Biology, Division of Stem Cell Biology Research, Cancer Center, Beckman Research Institute of City of Hope
- E. Tian
- Department of Developmental and Stem Cell Biology, Division of Stem Cell Biology Research, Cancer Center, Beckman Research Institute of City of Hope
- Guoqiang Sun
- Department of Developmental and Stem Cell Biology, Division of Stem Cell Biology Research, Cancer Center, Beckman Research Institute of City of Hope
- Jiehua Zhou
- Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope
- Guihua Sun
- Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of City of Hope
- Xiaoxuan Liu
- Aix-Marseille Université, CNRS, UMR 7325, Centre Interdisciplinaire de Nanoscience de Marseille
- Chao Chen
- Aix-Marseille Université, CNRS, UMR 7325, Centre Interdisciplinaire de Nanoscience de Marseille
- Kiyohito Murai
- Department of Developmental and Stem Cell Biology, Division of Stem Cell Biology Research, Cancer Center, Beckman Research Institute of City of Hope
- Chunnian Zhao
- Department of Developmental and Stem Cell Biology, Division of Stem Cell Biology Research, Cancer Center, Beckman Research Institute of City of Hope
- Krist T. Azizian
- Department of Molecular and Cellular Biology, Beckman Research Institute of City of Hope
- Lu Yang
- Integrative Genomics Core, Beckman Research Institute of City of Hope
- Charles Warden
- Integrative Genomics Core, Beckman Research Institute of City of Hope
- Xiwei Wu
- Integrative Genomics Core, Beckman Research Institute of City of Hope
- Massimo D'Apuzzo
- Department of Pathology, Beckman Research Institute of City of Hope
- Christine Brown
- Department of Hematology and Hematopoietic Cell Transplantation, Beckman Research Institute of City of Hope
- Behnam Badie
- Department of Surgery, Beckman Research Institute of City of Hope
- Ling Peng
- Aix-Marseille Université, CNRS, UMR 7325, Centre Interdisciplinaire de Nanoscience de Marseille
- Arthur D. Riggs
- Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of City of Hope
- John J. Rossi
- Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute of City of Hope
- Yanhong Shi
- Department of Developmental and Stem Cell Biology, Division of Stem Cell Biology Research, Cancer Center, Beckman Research Institute of City of Hope
- DOI
- https://doi.org/10.1038/ncomms10637
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
TLX is a nuclear receptor essential for neural stem cell self-renewal and recently involved in glioblastoma development. In this study, the authors show that inhibition of TLX expression, achieved using a dendrimer nanovector-delivered siRNAs or viral vector-delivered shRNAs, reduces glioblastoma stem cells self renewal and in vivotumour growth through activation of TET3.
