Nature Communications (Dec 2017)
Malaria parasite DNA-harbouring vesicles activate cytosolic immune sensors
- Xavier Sisquella,
- Yifat Ofir-Birin,
- Matthew A. Pimentel,
- Lesley Cheng,
- Paula Abou Karam,
- Natália G. Sampaio,
- Jocelyn Sietsma Penington,
- Dympna Connolly,
- Tal Giladi,
- Benjamin J. Scicluna,
- Robyn A. Sharples,
- Andreea Waltmann,
- Dror Avni,
- Eli Schwartz,
- Louis Schofield,
- Ziv Porat,
- Diana S. Hansen,
- Anthony T. Papenfuss,
- Emily M. Eriksson,
- Motti Gerlic,
- Andrew F. Hill,
- Andrew G. Bowie,
- Neta Regev-Rudzki
Affiliations
- Xavier Sisquella
- The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade
- Yifat Ofir-Birin
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Matthew A. Pimentel
- The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade
- Lesley Cheng
- Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne
- Paula Abou Karam
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Natália G. Sampaio
- The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade
- Jocelyn Sietsma Penington
- The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade
- Dympna Connolly
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2
- Tal Giladi
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Benjamin J. Scicluna
- Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne
- Robyn A. Sharples
- Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne
- Andreea Waltmann
- The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade
- Dror Avni
- The Institute of Geographic Medicine & Tropical Diseases and The laboratory for Tropical Diseases Research, Sheba Medical Center
- Eli Schwartz
- The Institute of Geographic Medicine & Tropical Diseases and The laboratory for Tropical Diseases Research, Sheba Medical Center
- Louis Schofield
- The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade
- Ziv Porat
- Flow Cytometry unit, Life Sciences Core Facilities, Weizmann Institute of Science
- Diana S. Hansen
- The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade
- Anthony T. Papenfuss
- The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade
- Emily M. Eriksson
- The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade
- Motti Gerlic
- Department of Clinical Microbiology and Immunology, Sackler Faculty of Medicine, Tel Aviv University
- Andrew F. Hill
- Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne
- Andrew G. Bowie
- School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2
- Neta Regev-Rudzki
- Department of Biomolecular Sciences, Weizmann Institute of Science
- DOI
- https://doi.org/10.1038/s41467-017-02083-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
STING is an intracellular DNA sensor that can alter response to infection, but in the case of malaria it is unclear how parasite DNA in red blood cells (RBCs) reaches DNA sensors in immune cells. Here the authors show that STING in human monocytes can sense P. falciparum nucleic acids transported from infected RBCs via parasite extracellular vesicles.
