Cancer Management and Research (Feb 2021)
Research Progress of Preoperative FPR, FAR or AFR in Patients with Colorectal Cancer
Abstract
Chen Chen, Yanlong Liu, Peng Han, Binbin Cui Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, Heilongjiang Province, People’s Republic of ChinaCorrespondence: Binbin CuiDepartment of Colorectal Surgery, Harbin Medical University Cancer Hospital, No. 150 Raod Haping, Nangang District, Harbin, 150081, Heilongjiang Province, People’s Republic of ChinaTel +13351112888Email [email protected]: Research has confirmed that plasma albumin (Alb), prealbumin (PA) and fibrinogen (Fib) are involved in regulating the occurrence and development of various tumors. Their levels in peripheral blood are related to the survival outcome and treatment response of patients, but the accuracy and specificity of single application have yet to be fully realized. A growing amount of evidence indicates that predictors such as preoperative fibrinogen to prealbumin ratio (FPR), fibrinogen to albumin ratio (FAR) or albumin to fibrinogen ratio (AFR) are emerging as comprehensive indicators. Indeed, their components play a key regulatory role in the progression of colorectal cancer (CRC). Preoperative FPR, FAR or AFR levels, therefore, are expected to become new biomarkers for prognosis evaluation and curative effect prediction for CRC patients and are significant in the guidance they could provide for the development of individualized treatment strategies.Keywords: colorectal cancer, FPR, FAR or AFR, prognosis, efficacy
