Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota

Chen Song; Fangyuan Duan; Ting Ju; Yue Qin; Deyong Zeng; Shan Shan; Yudong Shi; Yingchun Zhang; Weihong Lu

doi:10.1038/s42003-022-03602-7

Communications Biology (Jul 2022)

Eleutheroside E supplementation prevents radiation-induced cognitive impairment and activates PKA signaling via gut microbiota

Chen Song,
Fangyuan Duan,
Ting Ju,
Yue Qin,
Deyong Zeng,
Shan Shan,
Yudong Shi,
Yingchun Zhang,
Weihong Lu

Affiliations

Chen Song: School of Chemistry and Chemical Engineering, Harbin Institute of Technology
Fangyuan Duan: School of Chemistry and Chemical Engineering, Harbin Institute of Technology
Ting Ju: School of Chemistry and Chemical Engineering, Harbin Institute of Technology
Yue Qin: School of Chemistry and Chemical Engineering, Harbin Institute of Technology
Deyong Zeng: School of Chemistry and Chemical Engineering, Harbin Institute of Technology
Shan Shan: School of Chemistry and Chemical Engineering, Harbin Institute of Technology
Yudong Shi: School of Chemistry and Chemical Engineering, Harbin Institute of Technology
Yingchun Zhang: School of Chemistry and Chemical Engineering, Harbin Institute of Technology
Weihong Lu: School of Chemistry and Chemical Engineering, Harbin Institute of Technology

DOI: https://doi.org/10.1038/s42003-022-03602-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

Read online

The potential therapeutic value of Eleutheroside E in radiation-induced cognitive and memory impairments is regulated by the gut microbiota via neurotransmitter systems and PKA/CREB/BDNF signaling pathways.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal