Nature Communications (Apr 2016)

Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3

  • Wei-Sheng Chen,
  • Zhiyi Cao,
  • Satoshi Sugaya,
  • Maria J. Lopez,
  • Victor G. Sendra,
  • Nora Laver,
  • Hakon Leffler,
  • Ulf J. Nilsson,
  • Jianxin Fu,
  • Jianhua Song,
  • Lijun Xia,
  • Pedram Hamrah,
  • Noorjahan Panjwani

DOI
https://doi.org/10.1038/ncomms11302
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 19

Abstract

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Pathological lymphangiogenesis is associated with various eye diseases. Here the authors show that a carbohydrate-binding protein, galectin-8, promotes pathological lymphangiogenesis in the eye by regulating the crosstalk among VEGF-C, podoplanin and integrin pathways, and thus may represent a useful therapeutic target.