Scientific Data (Jul 2024)
Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center
- Maria Victoria Fernandez,
- Menghan Liu,
- Aleksandra Beric,
- Matt Johnson,
- Arda Cetin,
- Maulik Patel,
- John Budde,
- Pat Kohlfeld,
- Kristy Bergmann,
- Joseph Lowery,
- Allison Flynn,
- William Brock,
- Brenda Sanchez Montejo,
- Jen Gentsch,
- Nicholas Sykora,
- Joanne Norton,
- Jen Gentsch,
- Olga Valdez,
- Priyanka Gorijala,
- Jessie Sanford,
- Yichen Sun,
- Ciyang Wang,
- Dan Western,
- Jigyasha Timsina,
- Tassia Mangetti Goncalves,
- Anh N. Do,
- Yun Ju Sung,
- Guoyan Zhao,
- John C. Morris,
- Krista Moulder,
- David M. Holtzman,
- Randall J. Bateman,
- Celeste Karch,
- Jason Hassenstab,
- Chengjie Xiong,
- Suzanne E. Schindler,
- Joyce (Joy) Balls-Berry,
- Tammie L. S. Benzinger,
- Richard J. Perrin,
- Andrea Denny,
- B. Joy Snider,
- Susan L. Stark,
- Laura Ibanez,
- Carlos Cruchaga
Affiliations
- Maria Victoria Fernandez
- Department of Psychiatry, Washington University School of Medicine
- Menghan Liu
- Department of Psychiatry, Washington University School of Medicine
- Aleksandra Beric
- Department of Psychiatry, Washington University School of Medicine
- Matt Johnson
- Department of Psychiatry, Washington University School of Medicine
- Arda Cetin
- Department of Psychiatry, Washington University School of Medicine
- Maulik Patel
- Department of Psychiatry, Washington University School of Medicine
- John Budde
- Department of Psychiatry, Washington University School of Medicine
- Pat Kohlfeld
- Department of Psychiatry, Washington University School of Medicine
- Kristy Bergmann
- Department of Psychiatry, Washington University School of Medicine
- Joseph Lowery
- Department of Psychiatry, Washington University School of Medicine
- Allison Flynn
- Department of Psychiatry, Washington University School of Medicine
- William Brock
- Department of Psychiatry, Washington University School of Medicine
- Brenda Sanchez Montejo
- Department of Psychiatry, Washington University School of Medicine
- Jen Gentsch
- Department of Psychiatry, Washington University School of Medicine
- Nicholas Sykora
- Department of Psychiatry, Washington University School of Medicine
- Joanne Norton
- Department of Psychiatry, Washington University School of Medicine
- Jen Gentsch
- Department of Psychiatry, Washington University School of Medicine
- Olga Valdez
- Department of Psychiatry, Washington University School of Medicine
- Priyanka Gorijala
- Department of Psychiatry, Washington University School of Medicine
- Jessie Sanford
- Department of Psychiatry, Washington University School of Medicine
- Yichen Sun
- Department of Psychiatry, Washington University School of Medicine
- Ciyang Wang
- Department of Psychiatry, Washington University School of Medicine
- Dan Western
- Department of Psychiatry, Washington University School of Medicine
- Jigyasha Timsina
- Department of Psychiatry, Washington University School of Medicine
- Tassia Mangetti Goncalves
- Department of Genetics, Washington University School of Medicine
- Anh N. Do
- Department of Psychiatry, Washington University School of Medicine
- Yun Ju Sung
- Department of Psychiatry, Washington University School of Medicine
- Guoyan Zhao
- Department of Genetics, Washington University School of Medicine
- John C. Morris
- Department of Neurology, Washington University School of Medicine
- Krista Moulder
- Department of Neurology, Washington University School of Medicine
- David M. Holtzman
- Department of Neurology, Washington University School of Medicine
- Randall J. Bateman
- Department of Neurology, Washington University School of Medicine
- Celeste Karch
- Department of Psychiatry, Washington University School of Medicine
- Jason Hassenstab
- Department of Neurology, Washington University School of Medicine
- Chengjie Xiong
- Division of Biostatistics, Washington University School of Medicine
- Suzanne E. Schindler
- Department of Neurology, Washington University School of Medicine
- Joyce (Joy) Balls-Berry
- Department of Neurology, Washington University School of Medicine
- Tammie L. S. Benzinger
- Department of Neurology, Washington University School of Medicine
- Richard J. Perrin
- Pathology and Immunology Department, Washington University School of Medicine
- Andrea Denny
- Department of Neurology, Washington University School of Medicine
- B. Joy Snider
- Department of Neurology, Washington University School of Medicine
- Susan L. Stark
- Knight Alzheimer Disease Research Center, Washington University School of Medicine
- Laura Ibanez
- Department of Psychiatry, Washington University School of Medicine
- Carlos Cruchaga
- Department of Psychiatry, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/s41597-024-03485-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 19
Abstract
Abstract The Knight-Alzheimer Disease Research Center (Knight-ADRC) at Washington University in St. Louis has pioneered and led worldwide seminal studies that have expanded our clinical, social, pathological, and molecular understanding of Alzheimer Disease. Over more than 40 years, research volunteers have been recruited to participate in cognitive, neuropsychologic, imaging, fluid biomarkers, genomic and multi-omic studies. Tissue and longitudinal data collected to foster, facilitate, and support research on dementia and aging. The Genetics and high throughput -omics core (GHTO) have collected of more than 26,000 biological samples from 6,625 Knight-ADRC participants. Samples available include longitudinal DNA, RNA, non-fasted plasma, cerebrospinal fluid pellets, and peripheral blood mononuclear cells. The GHTO has performed deep molecular profiling (genomic, transcriptomic, epigenomic, proteomic, and metabolomic) from large number of brain (n = 2,117), CSF (n = 2,012) and blood/plasma (n = 8,265) samples with the goal of identifying novel risk and protective variants, identify novel molecular biomarkers and causal and druggable targets. Overall, the resources available at GHTO support the increase of our understanding of Alzheimer Disease.
