International Journal of General Medicine (Sep 2021)

Evaluation on the Distribution of EGFR, KRAS and BRAF Genes and the Expression of PD-L1 in Different Types of Lung Cancer

  • Zhao R,
  • Gao S,
  • He H,
  • Zhang J,
  • Zhang G,
  • Wen X

Journal volume & issue
Vol. Volume 14
pp. 5615 – 5620

Abstract

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Rui Zhao, Shan Gao, Haiqi He, Jia Zhang, Guangjian Zhang, Xiaopeng Wen Department of Thoracic Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaCorrespondence: Xiaopeng WenDepartment of Thoracic Surgery, First Affiliated Hospital of Xi’an Jiaotong University, #277 West Yanta Road, Xi’an City, Shaanxi Province, 710061, People’s Republic of ChinaEmail [email protected]: To evaluate the distribution of high frequency mutant genes and the expression of PDL1 in different types of lung cancer.Methods: This retrospective analysis was conducted on 330 patients who were diagnosed with primary lung cancer and treated in our hospital from October 2018 to October 2020. The patients were listed into non-small cell carcinoma group (101 cases), squamous carcinoma group (28 cases) and adenocarcinoma group (201 cases) according to their pathological results. The gene mutations were detected using EGFR, KRAS, and BRAF gene mutation detection kits, and the expression of PDL1 was detected by immunostaining. The mutation of EGFR, KRAS and BRAF genes and PDL1 expression in patients with different types of lung cancer were compared.Results: The patients in the adenocarcinoma group had the highest incidence of EGFR gene mutation, the mutation rate of the gene whose mutation location was exon 18 was significantly higher, and the difference between each group was statistically significant (P 0.05). PD-L1 expression in NSCLC patients was significantly higher than that in other lung cancer patients (P < 0.05).Conclusion: EGFR and KRAS genes showed obvious specific expressions in patients with different types of lung cancer and they were more common in patients with lung adenocarcinoma. Gene mutation and PDL1 expression are high in patients with lung adenocarcinoma.Keywords: lung cancer, typing, gene mutation, PD-L1

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