Nature Communications (Nov 2016)
Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
- Elisa Romanelli,
- Doron Merkler,
- Aleksandra Mezydlo,
- Marie-Theres Weil,
- Martin S. Weber,
- Ivana Nikić,
- Stephanie Potz,
- Edgar Meinl,
- Florian E. H. Matznick,
- Mario Kreutzfeldt,
- Alexander Ghanem,
- Karl-Klaus Conzelmann,
- Imke Metz,
- Wolfgang Brück,
- Matthew Routh,
- Mikael Simons,
- Derron Bishop,
- Thomas Misgeld,
- Martin Kerschensteiner
Affiliations
- Elisa Romanelli
- Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
- Doron Merkler
- Department of Pathology and Immunology, University of Geneva
- Aleksandra Mezydlo
- Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
- Marie-Theres Weil
- Max-Planck Institute of Experimental Medicine
- Martin S. Weber
- Department of Neurology, Georg-August University Göttingen
- Ivana Nikić
- Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
- Stephanie Potz
- Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
- Edgar Meinl
- Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
- Florian E. H. Matznick
- Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
- Mario Kreutzfeldt
- Department of Pathology and Immunology, University of Geneva
- Alexander Ghanem
- Max von Pettenkofer-Institute and Gene Center, Ludwig-Maximilians University Munich
- Karl-Klaus Conzelmann
- Max von Pettenkofer-Institute and Gene Center, Ludwig-Maximilians University Munich
- Imke Metz
- Institute of Neuropathology, Georg-August University Göttingen
- Wolfgang Brück
- Institute of Neuropathology, Georg-August University Göttingen
- Matthew Routh
- Department of Physiology and Health Science, Ball State University
- Mikael Simons
- Max-Planck Institute of Experimental Medicine
- Derron Bishop
- Department of Cellular and Integrative Physiology and Stark Neurosciences Research Institute, Indiana University School of Medicine
- Thomas Misgeld
- German Center for Neurodegenerative Diseases (DZNE)
- Martin Kerschensteiner
- Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich
- DOI
- https://doi.org/10.1038/ncomms13275
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
Oligodendrocyte damage is a key component of demyelinating diseases. Here, the authors use in vivolight and correlated electron microscopy in EAE mouse models, and find early damage occurs at the myelin sheath before spreading to the oligodendrocyte cell body.
