Fatty Acid Derivatives Isolated from the Oil of <i>Persea americana</i> (Avocado) Protects against Neomycin-Induced Hair Cell Damage
SeonJu Park,
Seo Yule Jeong,
Youn Hee Nam,
Jun Hyung Park,
Isabel Rodriguez,
Ji Heon Shim,
Tamanna Yasmin,
Hee Jae Kwak,
Youngse Oh,
Mira Oh,
Kye Wan Lee,
Jung Suk Lee,
Do Hoon Kim,
Yu Hwa Park,
In Seok Moon,
Se-Young Choung,
Kwang Won Jeong,
Bin Na Hong,
Seung Hyun Kim,
Tong Ho Kang
Affiliations
SeonJu Park
Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea
Seo Yule Jeong
Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea
Youn Hee Nam
Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea
Jun Hyung Park
Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea
Isabel Rodriguez
Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea
Ji Heon Shim
Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea
Tamanna Yasmin
Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea
Hee Jae Kwak
Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea
Youngse Oh
Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea
Mira Oh
Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea
Kye Wan Lee
R&D Center, Dongkook Pharm. Co. Ltd., Gyeonggi 16229, Korea
Jung Suk Lee
R&D Center, Dongkook Pharm. Co. Ltd., Gyeonggi 16229, Korea
Do Hoon Kim
R&D Center, Dongkook Pharm. Co. Ltd., Gyeonggi 16229, Korea
Yu Hwa Park
R&D Center, Dongkook Pharm. Co. Ltd., Gyeonggi 16229, Korea
In Seok Moon
Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul 03722, Korea
Se-Young Choung
Department of Preventive Pharmacy and Toxicology, College of Pharmacy, Kyung Hee University, Seoul 02453, Korea
Kwang Won Jeong
Gachon Institute of Pharmaceutical Sciences, College of Pharmacy, Gachon University, Incheon 21936, Korea
Bin Na Hong
Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea
Seung Hyun Kim
Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Korea
Tong Ho Kang
Department of Oriental Medicine Biotechnology, College of Life Sciences and Graduate School of Biotechnology, Kyung Hee University, Gyeonggi 17104, Korea
Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.
