Urology Case Reports (Jul 2024)

Anaplastic lymphoma kinase rearrangement-associated renal cell carcinoma: Rare subset case report

  • Hamad S. AlAkrash,
  • Hisham M. Ghabbani,
  • Faisal A. AlSaleh,
  • Rashad M. Nassar,
  • Almaha A. AlHumaidan,
  • Abdullateef M. AlHasan,
  • Abdullah M. AlMosa,
  • Abdulaziz A. AlBluwi,
  • Hossam S. Eltholoth,
  • Nagoud M. Ali,
  • Ahmed Y. AlZahrani

Journal volume & issue
Vol. 55
p. 102798

Abstract

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Anaplastic lymphoma kinase rearrangement-associated renal cell carcinoma (ALK-RCC) is a rare subtype of renal cell carcinoma characterized by genetic rearrangements involving the ALK gene. Managing ALK-RCC is challenging due to its rarity and limited treatment options. Targeted therapies directed at the ALK gene have shown promise.ALK-RCC is a rare subtype of renal cell carcinoma with unique clinical and pathological features. ALK inhibitors may hold promise as a targeted therapy for ALK-RCC. Further research is needed to understand the behavior of ALK-RCC and develop effective treatment strategies.