Advanced Science (Apr 2025)
Electret‐Inspired Charge‐Injected Hydrogel for Scar‐Free Healing of Bacterially Infected Burns Through Bioelectrical Stimulation and Immune Modulation
- Mujie Liu,
- Yuheng Wang,
- Haodong Wang,
- Lihong Qi,
- Yuxuan Shang,
- Jiajie Song,
- Xiulong Feng,
- Yiwei Chen,
- Waqar Ali Memon,
- Yuping Shen,
- Xiaodong Wu,
- Jiangbei Cao,
- Yifan Zhao,
- Zhuangde Jiang,
- Dingxin Liu,
- Shareen Shafique,
- Shengtao Li,
- Guanghao Lu,
- Zhixiang Wei,
- Zhijie Liu,
- Kun Zhou,
- Yuping Quan,
- Xiaoyu Zhang,
- Xin Zou,
- Xuefeng Wang,
- Na Liu,
- Yaqing Zhang,
- Yiwei Hu,
- Chao Han,
- Wen Wang
Affiliations
- Mujie Liu
- Functional and Molecular Imaging Key Lab of Shaanxi Province Department of Radiology Tangdu Hospital Air Force Medical University Xi'an 710032 China
- Yuheng Wang
- Functional and Molecular Imaging Key Lab of Shaanxi Province Department of Radiology Tangdu Hospital Air Force Medical University Xi'an 710032 China
- Haodong Wang
- Health Science Center Ningbo University Ningbo 315211 China
- Lihong Qi
- Department of Geriatric Medicine The Affiliated Hospital of Southwest Medical University Luzhou 646000 China
- Yuxuan Shang
- Functional and Molecular Imaging Key Lab of Shaanxi Province Department of Radiology Tangdu Hospital Air Force Medical University Xi'an 710032 China
- Jiajie Song
- Functional and Molecular Imaging Key Lab of Shaanxi Province Department of Radiology Tangdu Hospital Air Force Medical University Xi'an 710032 China
- Xiulong Feng
- Functional and Molecular Imaging Key Lab of Shaanxi Province Department of Radiology Tangdu Hospital Air Force Medical University Xi'an 710032 China
- Yiwei Chen
- Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200233 China
- Waqar Ali Memon
- Shenzhen Grubbs Institute and Department of Chemistry Southern University of Science and Technology Shenzhen 518055 China
- Yuping Shen
- The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310000 China
- Xiaodong Wu
- Department of Anesthesiology the First Medical Center of Chinese PLA General Hospital Beijing 100853 China
- Jiangbei Cao
- Department of Anesthesiology the First Medical Center of Chinese PLA General Hospital Beijing 100853 China
- Yifan Zhao
- State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies School of Instrument Science and Technology Xi'an Jiaotong University Xi'an 710049 China
- Zhuangde Jiang
- State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies School of Instrument Science and Technology Xi'an Jiaotong University Xi'an 710049 China
- Dingxin Liu
- State Key Laboratory of Electrical Insulation and Power Equipment Centre for Plasma Biomedicine, School of Electrical Engineering Xi'an Jiaotong University Xi'an 710049 China
- Shareen Shafique
- State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies School of Instrument Science and Technology Xi'an Jiaotong University Xi'an 710049 China
- Shengtao Li
- State Key Laboratory of Electrical Insulation and Power Equipment Centre for Plasma Biomedicine, School of Electrical Engineering Xi'an Jiaotong University Xi'an 710049 China
- Guanghao Lu
- State Key Laboratory of Electrical Insulation and Power Equipment Centre for Plasma Biomedicine, School of Electrical Engineering Xi'an Jiaotong University Xi'an 710049 China
- Zhixiang Wei
- CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China
- Zhijie Liu
- State Key Laboratory of Electrical Insulation and Power Equipment Centre for Plasma Biomedicine, School of Electrical Engineering Xi'an Jiaotong University Xi'an 710049 China
- Kun Zhou
- School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen (CUHK‐Shenzhen) Guangdong 518172 China
- Yuping Quan
- Department of Plastic Surgery and Regenerative Medicine Fujian Medical University Union Hospital Fuzhou 350001 China
- Xiaoyu Zhang
- Department of Medical Engineering Xinqiao Hospital Army Medical University Chongqing 400037 China
- Xin Zou
- Department of Medical Engineering Xinqiao Hospital Army Medical University Chongqing 400037 China
- Xuefeng Wang
- Functional and Molecular Imaging Key Lab of Shaanxi Province Department of Radiology Tangdu Hospital Air Force Medical University Xi'an 710032 China
- Na Liu
- Functional and Molecular Imaging Key Lab of Shaanxi Province Department of Radiology Tangdu Hospital Air Force Medical University Xi'an 710032 China
- Yaqing Zhang
- Department of Pediatric Orthopaedics Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China
- Yiwei Hu
- Department of Orthopedic Surgery Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200233 China
- Chao Han
- The Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou 310000 China
- Wen Wang
- Functional and Molecular Imaging Key Lab of Shaanxi Province Department of Radiology Tangdu Hospital Air Force Medical University Xi'an 710032 China
- DOI
- https://doi.org/10.1002/advs.202411889
- Journal volume & issue
-
Vol. 12,
no. 13
pp. n/a – n/a
Abstract
Abstract In this study, an electret‐inspired, charge‐injected hydrogel called QOSP hydrogel (QCS/OD/SDI/PANI/PS/Plasma) that promotes scar‐free healing of bacteria‐infected burns through bioelectrical stimulation and immune modulation, is presented. The hydrogel, composed of quaternized chitosan (QCS), oxidized dextran (OD), sulfadiazine (SDI), polystyrene (PS), and polyaniline nanowires (PANI), forms a conductive network capable of storing and releasing electric charges, emulating an electret‐like mechanism. This structure delivers bioelectrical signals continuously, enhancing wound healing by regulating immune responses and minimizing fibrosis. In a mouse model of second‐degree burns infected with Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the hydrogel accelerates wound healing by 32% and reduces bacterial load by 60%, significantly inhibited scar formation by 40% compared to controls. QOSP hydrogel modulates the Th1/Th2 immune balance toward a Th1‐dominant antifibrotic state through quaternized chitosan, thereby reducing collagen deposition by 35%. Electro‐dielectric characterization reveals a dielectric constant of 6.2, a 34% improvement in conductivity (3.33 × 10−5 S/m) and a 30 °C increase in thermal stability. Proteomic analysis highlights a 50% down‐regulation of pro‐inflammatory and pro‐fibrotic pathways, suggesting a controlled immune response conducive to scar‐free healing. This study underscores the potential of bioelectrically active hydrogels as a novel approach for treating infected wounds prone to scarring.
Keywords
- bacterially infected burns
- bioelectrical stimulation
- charge‐injected hydrogel
- electrets
- fibrosis inhibition
- immune modulation
