Nature Communications (Nov 2021)

A general strategy for C(sp3)–H functionalization with nucleophiles using methyl radical as a hydrogen atom abstractor

  • Isabelle Nathalie-Marie Leibler,
  • Makeda A. Tekle-Smith,
  • Abigail G. Doyle

DOI
https://doi.org/10.1038/s41467-021-27165-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

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When carbon-based units are functionalized in photoredox catalysis, electrophilic coupling partners are often used, such that the polarities of the two fragments are appropriately matched. Here the authors show a generalized methodology to instead use nucleophilic coupling partners, which are cheaper and often simpler, via successive hydrogen atom transfer and oxidative radical-polar crossover.