Nature Communications (Jun 2017)

The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism

  • Sebastian Kaiser,
  • Florian Sauer,
  • Caroline Kisker

DOI
https://doi.org/10.1038/ncomms15907
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

Read online

RecQ helicases are important for maintaining genomic integrity. Here, the authors present functional data and the crystal structure of human RecQ4, which exerts a helicase mechanism that may be more closely related to bacterial RecQ helicases than to its human family members.