The association between new generation oral contraceptive pill and the development of inflammatory bowel diseases

Intestinal Research. 2018;16(3):409-415 DOI 10.5217/ir.2018.16.3.409

 

Journal Homepage

Journal Title: Intestinal Research

ISSN: 1598-9100 (Print); 2288-1956 (Online)

Publisher: Korean Association for the Study of Intestinal Diseases

Society/Institution: Asian Organization for Crohn's and Colitis

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the digestive system. Gastroenterology

Country of publisher: Korea, Republic of

Language of fulltext: English

Full-text formats available: PDF, HTML, XML

 

AUTHORS

Santosh Sanagapalli (Gastroenterology and Liver Services, Concord Repatriation General Hospital, Concord NSW, .Australia)
Yanna Ko (Gastroenterology and Liver Services, Concord Repatriation General Hospital, Concord NSW, .Australia)
Viraj Kariyawasam (Gastroenterology and Liver Services, Concord Repatriation General Hospital, Concord NSW, .Australia)
Siew C Ng (Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Science, Hong Kong, .China)
Whitney Tang (Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, Li Ka Shing Institute of Health Science, Hong Kong, .China)
Hithanadura Janaka de Silva (Faculty of Medicine, University of Kelaniya, Ragama, .Sri Lanka)
Minhu Chen (The First Affiliated Hospital of Sun Yat Sen University, Guangzhou, .China)
Kaichun Wu (Xijing Hospital, Fourth Military Medical University, Xian, .China)
Satimai Aniwan (King Chulalongkorn Memorial Hospital, Bangkok, .Thailand)
Ka Kei Ng (Hospital Conde S Januario, Macau, .China)
David Ong (National University Hospital of Singapore, .Singapore)
Qin Ouyang (West China Hospital, Sichuan University, Chengdu, .China)
Ida Hilmi (University of Malaya Medical Center, Kuala Lumpur, .Malaysia)
Marcellus Simadibrata (University of Indonesia, .Indonesia)
Pises Pisespongsa (Maharaj Nakorn Chiangmai Hospital, Chiangmai, .Thailand)
Saranya Gopikrishna (Gastroenterology and Liver Services, Concord Repatriation General Hospital, Concord NSW, .Australia)
Rupert W Leong (Gastroenterology and Liver Services, Concord Repatriation General Hospital, Concord NSW, .Australia)

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 38 weeks

 

Abstract | Full Text

Background/AimsTo examine the association between use of oral contraceptive pills (OCPs) and the risk of developing inflammatory bowel diseases (IBD), in a modern cohort.MethodsA prospective nested case-control study across sites in the Asia-Pacific region was conducted; involving female IBD cases and asymptomatic controls. Subjects completed a questionnaire addressing questions related to OCP use. Primary outcome was the risk of development of IBD of those exposed to OCP versus non-exposure. Secondary outcomes were development of Crohn's disease (CD) versus ulcerative colitis (UC), and whether age of first use of OCP use may be associated with risk of IBD.ResultsThree hundred and forty-eight female IBD cases (41% CD, median age: 43 years) and 590 female age-matched controls were recruited. No significant association was found between OCP use and the risk of IBD (odds ratio [OR], 1.65; 95% confidence interval, 0.77–3.13; P=0.22), CD (OR, 1.55) or UC (OR, 1.01). The lack of association persisted when results were adjusted for age and smoking. IBD cases commenced OCP use at a younger age than controls (18 years vs. 20 years, P=0.049).ConclusionsIn this large cohort of subjects from the Asia-Pacific region, we found a modest but not significantly increased risk of developing IBD amongst OCP users.