Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage

Abstract

Biological roles of Pumilio1 (PUM1) in ubiquitous cells remain unclear. Here we identify 48 degrading target mRNAs by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs. Further analysis revealed that cells respond to DNA damage by inhibiting PUM1-mediated mRNA decay to activate translesion synthesis (46/50).

Keywords

• pumilio
• rna stability
• rna-seq
• translesion synthesis