Scalable Biosynthetic Production of Knotted Peptides Enables ADME and Thermodynamic Folding Studies

• Christopher J. Schwalen,
• Charles Babu,
• Swastik Phulera,
• Qin Hao,
• Daniel Wall,
• David O. Nettleton,
• Tejas P. Pathak,
• Piro Siuti

Affiliations

Christopher J. Schwalen

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States

Charles Babu

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States

Swastik Phulera

Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States

Qin Hao

Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States

Daniel Wall

Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States

David O. Nettleton

Pharmacokinetic Sciences, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States

Tejas P. Pathak

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States

Piro Siuti

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States