Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, CNRS UMR 8246, INSERM, UMR-S 1130, Sorbonne Universités, University Pierre and Marie Curie, Paris, France
Pauline Obiang
Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, CNRS UMR 8246, INSERM, UMR-S 1130, Sorbonne Universités, University Pierre and Marie Curie, Paris, France
Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, CNRS UMR 8246, INSERM, UMR-S 1130, Sorbonne Universités, University Pierre and Marie Curie, Paris, France
Aurélie Watilliaux
Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, CNRS UMR 8246, INSERM, UMR-S 1130, Sorbonne Universités, University Pierre and Marie Curie, Paris, France
Institut de Neurosciences de la Timone, CNRS and Aix Marseille Université, Marseille, France
Christelle Rochefort
Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, CNRS UMR 8246, INSERM, UMR-S 1130, Sorbonne Universités, University Pierre and Marie Curie, Paris, France
Neuroscience Paris Seine, Cerebellum, Navigation and Memory Team, CNRS UMR 8246, INSERM, UMR-S 1130, Sorbonne Universités, University Pierre and Marie Curie, Paris, France
Multiple lines of evidence suggest that functionally intact cerebello-hippocampal interactions are required for appropriate spatial processing. However, how the cerebellum anatomically and physiologically engages with the hippocampus to sustain such communication remains unknown. Using rabies virus as a retrograde transneuronal tracer in mice, we reveal that the dorsal hippocampus receives input from topographically restricted and disparate regions of the cerebellum. By simultaneously recording local field potential from both the dorsal hippocampus and anatomically connected cerebellar regions, we additionally suggest that the two structures interact, in a behaviorally dynamic manner, through subregion-specific synchronization of neuronal oscillations in the 6–12 Hz frequency range. Together, these results reveal a novel neural network macro-architecture through which we can understand how a brain region classically associated with motor control, the cerebellum, may influence hippocampal neuronal activity and related functions, such as spatial navigation.
