Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs

Kyle Tucker; Savitha Sridharan; Hillel Adesnik; Stephen G. Brohawn

doi:10.1038/s41467-022-32441-7

Nature Communications (Aug 2022)

Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs

Kyle Tucker,
Savitha Sridharan,
Hillel Adesnik,
Stephen G. Brohawn

Affiliations

Kyle Tucker: Department of Molecular & Cell Biology, University of California Berkeley
Savitha Sridharan: Department of Molecular & Cell Biology, University of California Berkeley
Hillel Adesnik: Department of Molecular & Cell Biology, University of California Berkeley
Stephen G. Brohawn: Department of Molecular & Cell Biology, University of California Berkeley

DOI: https://doi.org/10.1038/s41467-022-32441-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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ChRmine is a bacteriorhodopsin-like cation channelrhodopsin (BCCR). Here, the authors present cryo-EM structures of ChRmine in apo- and retinal-bound forms to provide insight into channel activity in a BCCR and facilitate engineering of ChRmine-based optogenetic tools.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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