Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant <i>Myoporum bontioides</i> A. Gray
Li-Mei Dong,
Li-Lan Huang,
Hang Dai,
Qiao-Lin Xu,
Jin-Kui Ouyang,
Xu-Chao Jia,
Wen-Xiang Gu,
Jian-Wen Tan
Affiliations
Li-Mei Dong
State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China
Li-Lan Huang
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China
Hang Dai
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China
Qiao-Lin Xu
Guangdong Provincial Key Laboratory of Bio-control for the Forest Disease and Pest, Guangdong Academy of Forestry, Guangzhou 510520, China
Jin-Kui Ouyang
State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China
Xu-Chao Jia
Key Laboratory of Functional Foods, Ministry of Agriculture/Guangdong Key Laboratory of Agricultural Products Processing/Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China
Wen-Xiang Gu
College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China
Jian-Wen Tan
State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China
The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, which led to the isolation of two new sesquiterpene alkaloids (1 and 2) and six known furanosesquiterpenes (3⁻8). Their structures were elucidated on the basis of extensive analysis of their 1D, 2D NMR and mass spectroscopic data. These two new alkaloids (1 and 2) displayed potent anti-MRSA activity with MIC value of 6.25 μg/mL. This is the first report of sesquiterpene alkaloids from the plants of Myoporum genus and their anti-MRSA activity.